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Printable 4th grade reading comprehension worksheet with questions on the Columbian Exchange, Taino people, and smallpox vaccination.
Worksheet

Articles 4–7 Comprehension Questions

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This printable reading-comprehension worksheet asks 4th graders ten open-response questions tied to articles 4–7 on early American history and disease. Topics include Edward Jenner's smallpox vaccine, the Taino people and their encounter with Columbus, the Columbian Exchange, and the major crops grown by American Indians. Suitable for in-class reading practice, homework, or assessment after completing the assigned articles.

Subject:
Social Studies
Topic:
History
Grade Level:
4th Grade
Updated May 2026

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