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Vaccine history crossword featuring Edward Jenner and smallpox.
Crossword Puzzle

Vaccine History Crossword Puzzle

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About:

A 10-clue crossword introducing elementary students to vaccine history and Edward Jenner's discovery of the first vaccine. Clues cover key terms like smallpox, cowpox, and medicine, as well as Jenner himself and his famous test subject, James Phipps. Use it as a history lesson supplement or review activity for a unit on scientific discovery and public health.

Subject:
Social Studies
Topic:
History
Grade Level:
3rd – 5th Grades
Updated May 2026

How to Use This Crossword Puzzle

Print this crossword for classroom use, homework packets, or sub plans. Click 'View Crossword' to modify clues, adjust difficulty, or add your own words before downloading as a PDF. An answer key is included with every download.

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